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Glutathione is an important water-soluble antioxidant that plays a role in supporting muscles from free radicals.**

Among these, the MUC5B promoter variant (rs35705950) is the most prominent, conferring a greater than threefold increased risk for IPF and exceeding the effect of all other known variants combined [21, 22]

With further in-depth analysis of its regulatory network and continued optimization of activator design, SIRT1 holds significant potential as a breakthrough target for multi-pathway, systemic, and precise intervention in MASLD

Furthermore, ZLN005 treatment activates mitophagy, as manifested by increased expression of LC3-II and co-localization between LC3 and mitochondria, and the protective effects are abrogated in TFEB-knockdown cells, suggesting that PGC-1 activation improves mitochondrial dysfunction via TFEB-mediated autophagy